DNA damage at Lamina-Associated Domains triggers nuclear envelope reorganization and chromatin detachment to prevent nuclear envelope blebbing and genome instability.
Diana Rubio-Contreras, Sylvain Audibert, Joanna Fernández…·Evi Soutoglou
Author
Institute of Cancer ResearchORCID 0000-0001-6713-5776Unclaimed ORCID profile · follow to get notified of new preprints
10 papers
Recent·Most cited
Diana Rubio-Contreras, Sylvain Audibert, Joanna Fernández…·Evi Soutoglou
Umit Aliyaskarova, Özgün Özer, Mahafuzul Sumon…·Kok‐Lung Chan
This study identifies how the BTRR complex assembles on ultrafine DNA bridges through SLiM recognition by RMI1-RMI2, revealing spatiotemporal regulation during DNA repair and segregation.
Cherif Badja, Soraya Boushaki, Yogesh Kumar…·Serena Nik‐Zainal
This study identifies BCOR mutations in hiPSCs as a culture-adaptive state causing chromatin, transcriptomic, and proteomic changes, and develops a qPCR assay for detection.
Priyanka Paul Biswas, Dharitri CHAUDHURİ, Vishwas Mishra…·Gad M. Frankel
This study shows that aged mice have increased susceptibility to Citrobacter rodentium infection but retain distinct molecular and inflammatory responses depending on the pathogen's virulence.
Mercedes Pardo, Chiara Marcozzi, Karen A. Lane…·Jyoti Sharma Choudhary
This study uses PRISMA to identify and map novel ARID1A interactions at high sequence resolution, revealing new interactors and a regulatory mechanism involving CDK2 phosphorylation.
Susana Simoes‐Sousa, Noa Amin, Karen A. Lane…·Jessica A. Downs
This study shows ARID1A deficiency increases sensitivity to the G4 ligand pyridostatin due to impaired DNA repair, highlighting a role for ARID1A in G4 ligand-induced DNA damage responses.
Jogitha Selvarajah, Rayzel Candida Fernandes, Marc P. Lorentzen…·Charlotte Lynne Bevan
Priyanka Biswas, Julia Sanchez‐Garrido, Zuza Kozik…·Gad M. Frankel
The study identifies 12 accessory T3SS effectors in Citrobacter rodentium that influence infection outcomes without affecting virulence.
Peter R. Martin, Jadwiga Nieminuszczy, Zuza Kozik…·Wojciech Niedźwiedź
The paper identifies the CIP2A-TOPBP1 axis as a regulator of mitotic DNA repair pathways, showing it promotes MiDAS and MMEJ through distinct mechanisms.
Cherif Badja, Sophie Momen, Ching Chiek Koh…·Serena Nik‐Zainal
This study investigates neurodegeneration in Xeroderma pigmentosum using stem cell-derived neurons, identifying endoplasmic reticulum stress and UPS dysfunction as key factors and developing an early detection assay.