Author

Tom van der Wel

Leiden UniversityORCID 0000-0002-6449-3233Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Anna Floor StevensiD· 2 shared Cas van der HorstiD· 2 shared Laura H. HeitmaniD· 2 shared Mario van der SteltiD· 2 shared Benjámin BartiiD· 1 shared Berend GagesteiniD· 1 shared Christian DeuschleiD· 1 shared Daniele PiomelliiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

Anna Floor StevensORCID

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2 papers

Recent·Most cited

Glycosylation of anandamide and other bioactive N-acylethanolamines in mammalian cells and tissues

Anna Floor Stevens, Remco E.A. Peter, Berend Gagestein, Maria J. Ferraz, Eline Been, Tijn Vleeshouwer, Iakovia Ttofi, Richard J. B. H. N. van den Berg, Tom van der Wel, Laura V. de Paus, Christian Deuschle, Cas van der Horst, Laura H. Heitman, Marta Artola, Daniele Piomelli, , Mario van der Stelt

The paper identifies NAE glycosylation as a metabolic pathway that links endocannabinoid metabolism to lysosomal dysfunction and inflammation.

bioRxiv · Jul 21, 2026 · PreprintBiochemistry

The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles

Verena M. Straub, Benjámin Barti, Sebastian Tommi Tandar, Anna Floor Stevens, Noëlle van Egmond, Tom van der Wel, Na Zhu, Joel Rüegger, Cas van der Horst, Laura H. Heitman, Yulong Li, Nephi Stella, J. G. Coen van Hasselt, István Katona, Mario van der Stelt

The paper proposes an on-demand release model for endocannabinoid 2-AG via microvesicles, showing stimulus-dependent release regulated by PKC, DAGL, and Arf6.

Proceedings of the National Academy of Sciences · Feb 20, 2025Peer-reviewedNeuroscience