Laura H. Heitman

The paper identifies NAE glycosylation as a metabolic pathway that links endocannabinoid metabolism to lysosomal dysfunction and inflammation.

The paper presents cryo-EM structures of the human A3 adenosine receptor in three functional states, revealing a unique activation mechanism and a cryptic binding pocket.

The paper maps protein-protein interactions of 396 SLC transporters using interaction proteomics and functional assays, providing a resource for understanding SLC function and drug targeting.

This paper develops a TR-FRET-based assay to measure ligand binding kinetics for CB1R and CB2R, finding that D77 enables accurate determination of on- and off-rates for various agonists and antagonists.

The paper proposes an on-demand release model for endocannabinoid 2-AG via microvesicles, showing stimulus-dependent release regulated by PKC, DAGL, and Arf6.

This study analyzes somatic mutations in GPCRs across cancer patients and healthy individuals, identifying conserved mutation hotspots and prioritizing GPCRs for further cancer research.