Author

Berend Gagestein

Leiden UniversityORCID 0000-0002-0993-6812Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

Mario van der SteltiD· 3 shared Uwe GretheriD· 2 shared A.C. Harms· 1 shared A.M.R. van den Bosch· 1 shared Albert J. R. HeckiD· 1 shared Alex A. HennemaniD· 1 shared Alexandra ValeanuiD· 1 shared Alger Lazo Mori· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Mario van der SteltORCID

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3 papers

Recent·Most cited

Glycosylation of anandamide and other bioactive N-acylethanolamines in mammalian cells and tissues

Anna Floor Stevens, Remco E.A. Peter, Berend Gagestein, Maria J. Ferraz, Eline Been, Tijn Vleeshouwer, Iakovia Ttofi, Richard J. B. H. N. van den Berg, Tom van der Wel, Laura V. de Paus, Christian Deuschle, Cas van der Horst, Laura H. Heitman, Marta Artola, Daniele Piomelli, , Mario van der Stelt

The paper identifies NAE glycosylation as a metabolic pathway that links endocannabinoid metabolism to lysosomal dysfunction and inflammation.

bioRxiv · Jul 21, 2026 · PreprintBiochemistry

Foamy microglia link oxylipins to disease progression in multiple sclerosis

D. van der Vliet, X. Di, Tatiana M. Shamorkina, Claire Coulon-Bainier, Anto Pavlovic, I.A.C.M. van der Vliet, Y. Zeng, Will Macnair, Noëlle van Egmond, J.Q.A. Chen, A.M.R. van den Bosch, Hendrik J. Engelenburg, Dennis D. Wever, M.R.J. Mason, Wouter P. F. Driever, , Mario van der Stelt

The paper identifies foamy microglia as contributors to disease progression in secondary progressive MS, linking oxylipins to lesion expansion and proposing monoacylglycerol lipase as a therapeutic target.

Leiden Repository (Leiden University) · Jan 1, 2026Peer-reviewedNeuroscience

CellEKT: A robust chemical proteomics workflow to profile cellular target engagement of kinase inhibitors

Joel Rüegger, Berend Gagestein, Antonius P. A. Janssen, Alexandra Valeanu, Alger Lazo Mori, Marielle van der Peet, Michael S. Boutkan, Bogdan I. Florea, Alex A. Henneman, Remo Hochstrasser, Haiyan Wang, Paul Westwood, Andreas Topp, Patricia M. Gomez Barila, Jan Paul Medema, , Mario van der Stelt

CellEKT profiles cellular target engagement of kinase inhibitors using chemical proteomics to determine IC50 values across over 300 kinases and validate results with phosphoproteomics and NanoBRET.

Molecular & Cellular Proteomics · Apr 6, 2025Peer-reviewedCancer Biology