Shidong Xi

Metabolite accumulation mediates the shift between HOC and LOC phases in the Yeast Metabolic Cycle

The paper investigates the YMC phase transitions by integrating metabolic, chromatin, and transcriptional data, finding that metabolite accumulation mediates the shift between HOC and LOC phases.

Single Nucleotide Resolution 4sU Sequencing (SNU-Seq) reveals the transcriptional responsiveness of an epigenetically primed human genome

This paper introduces SNU-Seq and sf4sU-Seq methods to map nascent transcripts at single-nucleotide resolution, revealing transcriptional responsiveness in an epigenetically primed human genome.

Transcriptional changes are regulated by metabolic pathway dynamics but decoupled from protein levels

The paper shows that transcriptional changes during biological rhythms do not directly affect protein levels, which remain constant due to slow turnover rates and post-translational regulation.

H3K4me3 is neither instructive for, nor informed by, transcription.

The paper investigates the relationship between H3K4me3 and transcription, finding no direct instructive or informative link between the two on a genome-wide scale in budding yeast.