Andrew Angel

This study shows Spt4 regulates RNA polymerase II elongation and nucleosome positioning in yeast by facilitating movement through the +2 nucleosomal barrier.

The paper identifies that FACT binds partially unwrapped nucleosomes in transcribed genes and spreads along genes in a Chd1-dependent manner.

The paper investigates the transcriptional response to acute stress in yeast, identifying two components: dynamic +1 nucleosome positioning and global Pol2 stalling leading to early transcription termination.

This paper introduces SNU-Seq and sf4sU-Seq methods to map nascent transcripts at single-nucleotide resolution, revealing transcriptional responsiveness in an epigenetically primed human genome.

The paper shows that transcriptional changes during biological rhythms do not directly affect protein levels, which remain constant due to slow turnover rates and post-translational regulation.

The paper investigates the relationship between H3K4me3 and transcription, finding no direct instructive or informative link between the two on a genome-wide scale in budding yeast.

The paper shows antisense transcription affects sense transcript dynamics through a chromatin signature, with effects observed in yeast and human genes.