Author

Kirsty Foote

University of CambridgeORCID 0000-0002-2800-0171Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:human· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Helle Færk JørgenseniD· 2 shared James C K TayloriD· 2 shared Jordi LambertiD· 2 shared Krishnaa T. A. MahbubaniiD· 2 shared Martin R. BennettiD· 2 shared Matthew D. WorssamiD· 2 shared Nichola L. Figg· 2 shared Sebnem OciD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

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10 top collaborators · 36 mutual co-author links

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2 shared papersMolecular Biology

Helle Færk JørgensenORCID

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3 papers

Recent·Most cited

Identification of osteopontin as a positional and functional candidate gene for cardiac hypertrophy in the SHRSP rat

Cara Trivett, Tamara P. Martin, Amrita Asirvatham, Kirsty Foote, Aiste Monkeviciute, Wendy Beattie, Christopher M. Loughrey, John McClure, Anna F. Dominiczak, Delyth Graham, Martin McBride

The paper identifies osteopontin (Spp1) as a positional and functional candidate gene for cardiac hypertrophy in SHRSP rats through congenic strain analysis and transcriptome profiling.

bioRxiv · Aug 27, 2026 · PreprintGenetics

Delineation of a thrombin receptor-stimulated vascular smooth muscle cell transition generating cells in the plaque-stabilising fibrous cap

James C K Taylor, Matthew D. Worssam, Sebnem Oc, Jordi Lambert, Krishnaa T. A. Mahbubani, Kirsty Foote, Allie Finigan, Yee‐Hung Chan, Nichola L. Figg, Murray C.H. Clarke, Martin R. Bennett, Helle Færk Jørgensen

The paper identifies a VSMC transition linked to fibrous cap formation in atherosclerosis and shows PAR1 as a potential therapeutic target.

Cardiovascular Research · Jun 26, 2025Peer-reviewedMolecular Biology

Network-based prioritisation and validation of novel regulators of vascular smooth muscle cell proliferation in disease

Jordi Lambert, Sebnem Oc, Matthew D. Worssam, Daniel Häußler, Charles Ugochukwu Solomon, Nichola L. Figg, Ruby M. Baxter, Maria Imaz, James C K Taylor, Kirsty Foote, Alison J. Finigan, Krishnaa T. A. Mahbubani, Tom R. Webb, Shu Ye, Martin R. Bennett, , Helle Færk Jørgensen

The paper identifies and validates novel regulators of vascular smooth muscle cell proliferation using network analysis and experimental validation, highlighting RUNX1 and the TIMP1-CD74 axis as potential therapeutic targets.

Nature Cardiovascular Research · Jun 6, 2024Peer-reviewedMolecular Biology