Author

H. Ismail

Newcastle University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Acosta-Serrano· 1 shared A. Casas-Sanchez· 1 shared A. Dhabaria· 1 shared A. Gudur· 1 shared A. Pinto-Fernandez· 1 shared Alberto BarrosiD· 1 shared Alexandra Manuel LopesiD· 1 shared Aneta MikulášováiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBiochemistry

A. Acosta-Serrano

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Geranylgeranylated-SCFFBXO10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function

S. A. Bhat, Z. Vasi, L. Jiang, S. Selvaraj, R. Ferguson, A. Gudur, H. Ismail, R. Adhikari, A. Dhabaria, B. Ueberheide, S. Kuchay

This study identifies how geranylgeranylation of FBXO10 enables its targeting to the outer mitochondrial membrane, where it regulates PGAM5 ubiquitination and mitochondrial function.

bioRxiv · Apr 16, 2024 · PreprintCell Biology

Ubiquitinome analysis of articular cartilage post mechanical injury reveals a differential ubiquitination pattern of a subset of DUBs and proteins linked to the ERAD cellular response

N. Kaokhum, A. Pinto-Fernandez, J. M. Wilkinson, B. M. Kessler, H. Ismail

The paper identifies a unique ubiquitin signature in injured articular cartilage, linking ERAD pathway activation and DUB activity to tissue injury and osteoarthritis.

bioRxiv · Jan 19, 2022 · PreprintBiochemistry

A de novo paradigm for male infertility

Manon S. Oud, RM Smits, H E Smith, Francesco Kumara Mastrorosa, Giles S. Holt, Brendan J. Houston, Petra F. de Vries, B. Alobaidi, Lois E. Batty, H. Ismail, J. Greenwood, Harsh J. Sheth, Aneta Mikulášová, Galuh Astuti, Christian Gilissen, , Joris Andre Veltman

The paper identifies de novo mutations as a significant genetic cause of male infertility, finding several candidate genes and an enrichment of loss-of-function and missense mutations in intolerant genes.

Nature Communications · Jan 10, 2022Peer-reviewedGenetics

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

A. Acosta-Serrano, M. Sterkel, L. Haines, A. Casas-Sanchez, V. Owino, R. Vionette-Amaral, S. Quek, C. Rose, M. Silva dos Santos, N. Garcia Escude, H. Ismail, M. I. Paine, S. M. Barribeau, S. Wagstaff, J. I. MacRae, , P. L. Oliveira

This study shows that nitisinone can kill tsetse flies without harming bees, offering an eco-friendly method to control African trypanosomiasis transmission.

bioRxiv · Jun 8, 2020Biochemistry