Author

Jan Otto Wirth

Max Planck Institute for Medical ResearchORCID 0000-0002-6471-9626Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Approach:biophysical modeling· 1 Assay:electrophysiology· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

Arne GennerichiD· 1 shared Christopher Hampton· 1 shared Elisa D’EsteiD· 1 shared Jasmine HubrichiD· 1 shared Jessica MatthiasiD· 1 shared Johann EngelhardtiD· 1 shared Jonas M. SchleskeiD· 1 shared Lu RaoiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBiophysics

Arne GennerichORCID

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3 papers

Recent·Most cited

CLUSTERING DYNAMICALLY MODULATE THE BIOPHYSICS OF VOLTAGE-GATED SODIUM CHANNELS: HOW NANOSCALE PHENOMENA DETERMINE HEALTH AND DISEASE

Mikhail Tarasov, Madison Ammon, Jan Otto Wirth, Christopher Hampton, Zoja Selimi, Rengasayee Veeraraghavan, Przemysław Radwański

The paper shows that clustering of voltage-gated sodium channels affects their biophysics, leading to different pharmacological responses and potential therapeutic implications.

bioRxiv · May 31, 2025 · PreprintPhysiology

A Two-Heads-Bound State Drives KIF1A Superprocessivity

Lu Rao, Jan Otto Wirth, Jessica Matthias, Arne Gennerich

This study identifies a two-heads-bound state in KIF1A that enhances processivity and is critical for neuronal transport, contrasting with Kinesin-1's one-head-bound state.

bioRxiv · Jan 14, 2025 · PreprintBiophysics

MINFLUX Reveals Dynein Stepping in Live Neurons

Jonas M. Schleske, Jasmine Hubrich, Jan Otto Wirth, Elisa D’Este, Johann Engelhardt, Stefan W. Hell

This study uses MINFLUX to track dynein movement in live neurons, revealing 8 nm steps and rapid direction reversals, suggesting a single ATP-dependent stepping mechanism.

Proceedings of the National Academy of Sciences · Sep 10, 2024Peer-reviewedBiophysics