Rengasayee Veeraraghavan

Cardiac unloading via a transvalvular pump prevents arrhythmias following myocardial ischemia / reperfusion by preserving coronary microcirculation and cardiomyocyte nanostructure

This study shows that transvalvular unloading reduces arrhythmias after myocardial ischemia/reperfusion by preserving coronary microcirculation and cardiomyocyte nanostructure in a porcine model.

Selectivity filter mutation in NaV1.5 promotes ventricular tachycardia

This study investigates a NaV1.5 mutation linked to Brugada Syndrome, showing reduced sodium current and arrhythmia susceptibility in a mouse model.

CLUSTERING DYNAMICALLY MODULATE THE BIOPHYSICS OF VOLTAGE-GATED SODIUM CHANNELS: HOW NANOSCALE PHENOMENA DETERMINE HEALTH AND DISEASE

The paper shows that clustering of voltage-gated sodium channels affects their biophysics, leading to different pharmacological responses and potential therapeutic implications.

Indirect Correlative Light and Electron Microscopy (iCLEM): A Novel Pipeline for Multiscale Quantification of Structure from Molecules to Organs

The paper introduces iCLEM, a pipeline that correlates multiscale structural data from different imaging modalities using intrinsic fiducials, enabling structure-function relationship discovery.