Acute myeloid leukemia mitochondria hydrolyze ATP to resist chemotherapy
James T. Hagen, McLane M. Montgomery, Raphael Taiwo Aruleba, Brett R. Chrest, Polina M. Krassovskaia, Thomas D. Green, Emely A. Pacheco, Miki Kassai, Tonya N. Zeczycki, Cameron A. Schmidt, Debajit Bhowmick, Su‐Fern Tan, David J. Feith, Charles Edward Chalfant, Thomas P. Loughran, , Kelsey H. Fisher‐Wellman
This study identifies a bioenergetic mechanism in AML cells where mitochondria consume ATP to resist chemotherapy, offering a target for improving treatment.
Science Advances · Apr 9, 2025Peer-reviewedCancer Biology