Elmar G. Weinhold

The paper uses optical genome and epigenome mapping to identify somatic alterations in early-stage clear cell renal cell carcinoma, revealing both known and novel genomic and epigenomic changes.

The paper demonstrates a single DNA molecule-based genetic circuit that functions as a dissipative nanodevice by enabling coexpressional localization of proteins.

The paper introduces a method to simultaneously analyze 5-methylcytosine and 5-hydroxymethylcytosine in clinical samples, showing reduced 5-hydroxymethylcytosine in colorectal cancer and chronic lymphocytic leukaemia.

This paper develops a chemoenzymatic method to label non-methylated CpGs in DNA, enabling single-molecule epigenetic profiling in human and plant genomes.

R2OM2 creates fluorescent optical methylation profiles along chromosomal DNA for epigenetic profiling, comparable to WGBS with single-molecule resolution.

The paper introduces R2OM2, a method combining optical methylation profiling with genome mapping to analyze epigenetic variation in single cells and large structural aberrations.