Tslil Gabrieli

This paper develops a chemoenzymatic method to label non-methylated CpGs in DNA, enabling single-molecule epigenetic profiling in human and plant genomes.

This paper introduces a long-read optical mapping technology to profile 5-hydroxymethylcytosine (5-hmC) across the genome, revealing long-range epigenetic correlations and cell-to-cell variation.

R2OM2 creates fluorescent optical methylation profiles along chromosomal DNA for epigenetic profiling, comparable to WGBS with single-molecule resolution.

The paper introduces R2OM2, a method combining optical methylation profiling with genome mapping to analyze epigenetic variation in single cells and large structural aberrations.

The paper introduces a method to isolate and enrich large genomic regions for targeted analysis using Cas9 excision and pulsed field gel electrophoresis, enabling cost-effective detection of mutations and structural variants.