Author

Bjoern Chapuy

Dana-Farber Cancer InstituteORCID 0000-0002-6485-8773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Allison Tompkins· 1 shared Amy Li· 1 shared Anup VaidyaiD· 1 shared Arianna MarkeliD· 1 shared Benoît LaurentiD· 1 shared Caroline KubaczkaiD· 1 shared Cheng ZhangiD· 1 shared Christopher LiiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperGenomics

Allison Tompkins

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2 papers

Recent·Most cited

Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancers

Mohamad Ali Toufic Najia, Deepak Kumar Jha, Cheng Zhang, Benoît Laurent, Caroline Kubaczka, Arianna Markel, Christopher Li, Vivian Morris, Allison Tompkins, Luca T. Hensch, Yue Qin, Bjoern Chapuy, Yu-Chung Huang, Michael Morse, Matthew R. Marunde, , George Q. Daley

The paper identifies KDM4 demethylase inhibition as a therapeutic strategy for lymphoma and other cancers by rewiring heterochromatin and inducing DNA damage.

bioRxiv · Jan 31, 2025 · PreprintGenomics

iEDGE: integration of Epi-DNA and Gene Expression and applications to the discovery of somatic copy number-associated drivers in cancer

Amy Li, Bjoern Chapuy, Xaralabos Varelas, Paola Sebastiani B, Stefano Monti

iEDGE integrates epi-DNA and gene expression data to identify cis and trans driver genes in cancer, showing enrichment for known oncogenes and tumor suppressors.

bioRxiv · Mar 11, 2019 · PreprintBioinformatics