Author
Université de SherbrookeORCID 0000-0002-4032-3213Unclaimed ORCID profile · follow to get notified of new preprints
9 papers
Recent·Most cited
Dhanushka Hewa Bostanthirige, Camille Plante, Molly A. Caron, Suzanne Gascon, Maude Lévesque, Colin Poirier, Mathieu Deschênes, Jean-Paul Sabo Vatasescu, Benoı̂t Chabot, Sameh Geha, Benoît Laurent, Jean‐Philippe Brosseau
This study demonstrates that restoring NF1 gene expression in established neurofibromas can lead to tumor regression in mouse models.
Communications Biology · Feb 12, 2026Peer-reviewedCancer Biology
Floriane Bretheau, O.J. Arevalo, Vincent Gélinas, Louise Réveret, Océane Martinez, Marlie Ali Yandza, Bastien Jacquet, Léa Ferreira, Morgan Bérard, Charles Joly-Beauparlant, Steve Lacroix, Éric Boilard, Benoît Laurent, Frédéric Calon, Martin Parent, , Aurélie de Rus Jacquet
This study identifies Parkinson's disease risk genes expressed at brain barriers and shows poor transcript-protein correlation and low interspecies conservation.
bioRxiv · Oct 20, 2025 · PreprintNeuroscience
Olivier Dionne, Gabrielle-Lee Gaudreau, Clara Bergis, Mariano Avino, Salomé Sabatié, François Corbin, Benoît Laurent
This study identifies an H3K79me2-dependent epigenetic barrier in FXS neural progenitor cells, showing its dysregulation impairs proliferation and differentiation.
bioRxiv · Aug 31, 2025 · PreprintNeuroscience
Mohamad Ali Toufic Najia, Deepak Kumar Jha, Cheng Zhang, Benoît Laurent, Caroline Kubaczka, Arianna Markel, Christopher Li, Vivian Morris, Allison Tompkins, Luca T. Hensch, Yue Qin, Bjoern Chapuy, Yu-Chung Huang, Michael Morse, Matthew R. Marunde, , George Q. Daley
The paper identifies KDM4 demethylase inhibition as a therapeutic strategy for lymphoma and other cancers by rewiring heterochromatin and inducing DNA damage.
bioRxiv · Jan 31, 2025 · PreprintGenomics
Robert S. Porter, Sojin An, María Cecilia Gavilán, Masayoshi Nagai, Yumie Murata-Nakamura, Bo O. Zhou, Katherine M. Bonefas, Olivier Dionne, Jeru Manoj Manuel, Joannie St-Germain, Suzanne Gascon, Jacqueline I. Kim, Liam Browning, Benoît Laurent, Uhn‐Soo Cho, Shigeki Iwase
The paper identifies neuron-specific microexon splicing in chromatin regulators, showing that PHF21A loses DNA-binding function in neurons while retaining H3K4me0 recognition, contributing to brain development.
Cell Reports · Jan 1, 2025Peer-reviewedMolecular Biology
Jessica Avila Lopez, Clauda Abboud, Maged Ibrahim, Javier Rocha Ahumada, Mariano Avino, Mélanie Plourde, Karl J. L. Fernandes, C. Florian Bentzinger, Benoît Laurent
This study investigates the effects of cyclic in vivo OSKM reprogramming on the choroid plexus, finding limited transcriptomic changes but increased NKCC1 expression and minor morphological alterations.
bioRxiv · Feb 28, 2023 · PreprintNeuroscience
Viktoriia Bavykina, Mariano Avino, Mohammed Amir Husain, Adrien Zimmer, Hugo Parent-Roberge, Abdelouahed Khalil, Marie A. Brunet, Tamàs Fülöp, Benoît Laurent
This study identifies differentially expressed genes in peripheral blood monocytes across Alzheimer's disease stages, highlighting chemokine/cytokine pathways and potential biomarkers for early detection.
bioRxiv · Feb 28, 2023 · PreprintNeuroscience
Karine Bourgade, Eric H. Frost, Gilles Dupuis, Jacek Maciej Witkowski, Benoît Laurent, Charles Calmettes, Charles Ramassamy, Mathieu Desroches, Serafim Rodrigues, Tamàs Fülöp
The paper investigates the molecular interaction between HSV-1 glycoprotein B and Amyloid-β peptides using FRET to explore their role in virus neutralization.
Journal of Alzheimer s Disease Reports · Sep 19, 2022Peer-reviewedNeuroscience
Karol Kaiser, Ahram Jang, Petra Kompaníková, Melody P. Lun, Jan Procházka, Ondřej Machoň, Neil Dani, Michaela Procházková, Benoît Laurent, Daniel Gyllborg, Renée van Amerongen, Ryann M. Fame, Suhasini Gupta, Feizhen Wu, Roger A. Barker, , Vı́tězslav Bryja
This study identifies the MEIS-WNT5A axis as critical for the development and morphology of the fourth ventricle choroid plexus.
Development · Apr 26, 2021Peer-reviewedDevelopmental Biology