Deconvoluting drug interactions based on M. tuberculosis physiologic processes:Transcriptional disaggregation of the BPaL regimen in vivo
Elizabeth A. Wynn, Christian Dide-Agossou, Reem Al Mubarak, Karen Rossmassler, Jo Hendrix, Martin I. Voskuil, Andrés Obregón‐Henao, Michael A. Lyons, Gregory T. Robertson, Camille M. Moore, Nicholas D. Walter
The paper uses SEARCH-TB to analyze drug interactions in M. tuberculosis by measuring transcriptional responses to the BPaL regimen in vivo, showing complex effects of drug combinations.
bioRxiv · Feb 24, 2025 · PreprintGenomics