Karen Rossmassler

The paper presents a Trisomy 21 Model Atlas comparing mouse and human models to show conserved dosage effects and context-specific transcriptional responses across tissues and developmental stages.

This study compares M. tuberculosis physiology in high-dose and low-dose infection models, showing how adaptive immunity affects bacterial metabolism and drug efficacy.

This study investigates the physiologic recovery of Mycobacterium tuberculosis in mice after antibiotic treatment, finding that recovery is slow, sequential, and incomplete, with longer treatment leading to slower recovery.

The paper uses SEARCH-TB to analyze drug interactions in M. tuberculosis by measuring transcriptional responses to the BPaL regimen in vivo, showing complex effects of drug combinations.

This study examines how prolonged antibiotic treatment affects M. tuberculosis physiology in mice, finding that sterilizing and non-sterilizing antibiotics induce distinct transcriptional responses.