Pavel G Georgiev

Beyond DNA Binding: single C2H2 zinc fingers with adjacent β-strands mediate dimerization in Drosophila transcription factors

The paper identifies and characterizes a unique C2H2 zinc finger domain in Drosophila that mediates dimerization through a conserved CGEx motif, revealing its structural and evolutionary significance.

The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers

The paper identifies a unique hexameric structure of Arthropoda-specific TTK-type BTB domains and shows their lineage-specific expansion in insects.

The insulating activity of the Drosophila BX-C chromatin boundary Fub-1 is parasegmentally regulated by lncRNA read-through

The paper shows that lncRNA read-through from the Fub-1 boundary in Drosophila inactivates its insulating activity in PS6/A1.

Boundary Bypass Activity in the Abdominal-B Region of the Drosophila Bithorax Complex is Position Dependent and Regulated

The paper investigates bypass activity in Drosophila Abd-B regulatory boundaries, finding that bypass elements must be in the domain driving Abd-B expression and that bypass activity is location-dependent.

Transcriptional read through interrupts boundary function in Drosophila

The paper investigates how transcriptional readthrough affects boundary function in Drosophila BX-C, finding that it can impair boundary activity and influence enhancer function.

Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila

The paper determines the structural basis of the interaction between CLAMP and MSL2 proteins, showing how this interaction enables specific recruitment of the dosage compensation complex to the male X chromosome in Drosophila.

Redundant enhancers in the iab-5 domain cooperatively activate Abd-B in the A5 and A6 abdominal segments of Drosophila

The paper shows that redundant enhancers in the iab-5 domain cooperate with iab-4 and iab-6 domains to activate Abd-B in A5 and A6 abdominal segments of Drosophila.

Drosophila architectural protein CTCF is not essential for fly survival and is able to function independently of CP190

This study shows that dCTCF is not essential for Drosophila survival but is involved in Abd-B gene regulation and fertility, with functional compensation from other proteins.

Mechanism and functional role of the interaction between CP190 and the architectural protein Pita in Drosophila melanogaster

This study identifies two regions in Pita that interact with CP190 and shows that this interaction is critical for Pita's enhancer blocking activity but not required for its chromatin binding.

N-Terminus of Drosophila Melanogaster MSL1 Is Critical for Dosage Compensation

This study shows that the N-terminal region of MSL1 is essential for MSL complex stability and function in dosage compensation in Drosophila males.

Boundaries support specific long-distance interactions between enhancers and promoters in Drosophila Bithorax complex

The paper shows that boundaries in Drosophila BX-C both block crosstalk between regulatory domains and actively facilitate long-distance communication between domains and their target genes.

CLAMP directly interacts with MSL2 to facilitate Drosophila dosage compensation

This study shows that CLAMP directly interacts with MSL2 to aid in the recruitment of the MSL complex to the X chromosome in Drosophila.

The bithorax complex iab-7 Polycomb Response Element has a novel role in the functioning of the Fab-7 chromatin boundary

The paper identifies a novel role for the iab-7 Polycomb Response Element in boundary function by showing its interaction with the LBC and GAF protein, and reveals that HS1 alone can partially function as a boundary.