Xinyang Bing

The paper introduces Domino, a deep learning framework that models sequence-to-function relationships to uncover the context-specific grammar of Drosophila chromatin insulation.

The paper identifies distal and interchromosomal chromatin interactions in T cells using a new algorithm and links them to gene regulation through epigenomic analysis.

This study tests two models for TAD boundary formation in flies and finds that boundary pairing, not loop extrusion, determines TAD endpoints.

The paper shows that lncRNA read-through from the Fub-1 boundary in Drosophila inactivates its insulating activity in PS6/A1.

The paper shows that 3D chromatin organisation and gene regulation are independent during Drosophila dorsoventral patterning, with chromatin structure maintaining consistency across tissues despite differences in gene expression.

The paper shows that tRF-GG regulates noncoding RNA production and histone levels, affecting MERVL element repression through U7 snRNA and RNA-binding proteins.