Erica Larschan

The paper identifies common and sex-biased aging biomarkers in skeletal muscle transcriptomes across six species, revealing shared and divergent molecular mechanisms of aging.

This study identifies CLAMP as a transcription factor essential for Drosophila NSC differentiation and optic lobe development by regulating Notch and Tailless.

This study maps sex-specific RNA-RNA and RNA-DNA interactions in Drosophila cells using RD-SPRITE, revealing CLAMP's role in spliceosome targeting and RNA regulation.

The paper introduces TimeFlies, an snRNA-seq aging clock for Drosophila heads, identifies key lncRNAs as biomarkers, and shows sex-specific aging pathways.

The paper shows how differential binding of two GA-binding transcription factors regulates chromatin looping to create an X-specific environment for dosage compensation.

This study compares transcriptomic profiles of embryonic stem cells across mammals, identifying conserved and species-specific pluripotency mechanisms and markers.

This study identifies sex-biased gene expression, alternative splicing, and isoform dynamics in bovine embryos, linking male-biased metabolism to faster development and female-biased X-linked gene expression to sex-specific regulation.

OTVelo estimates gene velocities using optimal transport to infer dynamic gene regulatory networks from time-stamped single-cell gene expression data.

BindCompare identifies combinatorial TF-RBP binding interactions by comparing their nucleic acid targets across organisms, generating hypotheses for gene regulatory networks.

The paper identifies DEAF1 as a repressor of synaptic genes, showing its role in limiting synaptogenesis and linking it to intellectual disability.

scNODE predicts single-cell gene expression at unobserved timepoints using a deep learning model combining VAE and ODEs, improving trajectory inference and perturbation analysis.

The paper shows CLAMP, a DNA-binding factor, regulates sex-specific splicing by interacting with RNA and modulating RBP dynamics.

The paper identifies CLAMP as a transcription factor that regulates heat stress-induced repression of constitutive genes in Drosophila and presents a high-resolution 3D genomic dataset.

The paper develops histone mark-based age prediction models across tissues, showing comparable accuracy to DNA methylation predictors and identifying key developmental pathways involved in aging.

The paper identifies mechanisms by which the CLAMP TF regulates sex-specific splicing in Drosophila embryos through interactions with RBPs and gene regulation.

The paper introduces GC-MERGE, a graph convolutional model that integrates spatial genomic organization and histone modifications to predict gene expression and interpret regulatory factors.

The paper shows that CLAMP and Zelda work together to drive zygotic genome activation in Drosophila by enhancing chromatin accessibility and promoting transcription.

TIMEOR identifies temporal regulatory mechanisms from multi-omics data by inferring gene regulatory relationships across time, revealing a link between insulin stimulation and circadian rhythm.

This study investigates how ethanol deprivation affects behavior and gene expression in Drosophila, identifying molecular and neural changes associated with negative affect states.

This study identifies how the MSLc complex targets the X-chromosome in Drosophila embryos using meiotic drive and ChIP-seq, revealing a multi-stage process involving CLAMP binding sites.

This study shows that CLAMP directly interacts with MSL2 to aid in the recruitment of the MSL complex to the X chromosome in Drosophila.