Author

Bruna Lopes da Costa

Columbia UniversityORCID 0000-0002-6513-0717Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Peter M. J. QuinniD· 2 shared Ahmara G. RossiD· 1 shared Amy-Ann Edziah· 1 shared Andrew D. WellsiD· 1 shared Anne Marie Berry· 1 shared Chenqi TaoiD· 1 shared Diego F. BuenaventuraiD· 1 shared Eydie G. Miller-EllisiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenomics

Peter M. J. QuinnORCID

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2 papers

Recent·Most cited

Variant-to-gene mapping in ocular cell types identifies candidate effector genes for primary open-angle glaucoma

Vrathasha Vrathasha, Matthew C. Pahl, James A. Pippin, Sergei S. Nikonov, Jie He, Mina Halimitabrizi, Laxmi Moksha, Rebecca Salowe, Amy-Ann Edziah, Yuki Bradford, Yan Zhu, Harini V. Gudiseva, Venkata Ramana Murthy Chavali, Bruna Lopes da Costa, Anne Marie Berry, , Joan M. O’Brien

This study maps POAG risk variants to candidate effector genes in ocular cell types, identifying ARHGEF12 as a potential target.

bioRxiv · Sep 14, 2026 · PreprintGenomics

Phase transition specified by a binary code patterns the vertebrate eye cup

Revathi Balasubramanian, Xuanyu Min, Peter M. J. Quinn, Quentin Lo Giudice, Chenqi Tao, Karina Polanco, Neoklis Makrides, John Peregrin, Michael Bouaziz, Yingyu Mao, Qian Wang, Bruna Lopes da Costa, Diego F. Buenaventura, Fen Wang, Liang Ma, , Xin Zhang

The paper shows that FGF and Wnt signaling gradients determine phase transitions in vertebrate eye cup development, specifying cell fates through their combinatorial code.

Science Advances · Nov 10, 2021Peer-reviewedDevelopmental Biology