Author

Karina Polanco

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Developmental Biology· 3 Cell Biology· 1

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Revathi BalasubramanianiD· 4 shared Abdul Hannan· 2 shared Chenqi TaoiD· 2 shared Christa L. MontgomeryiD· 2 shared Fen WangiD· 2 shared John PeregriniD· 2 shared Krishnakumar KizhatiliD· 2 shared Liang MaiD· 2 shared

Activity by Year

2018-2026 · peak 1/yr

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10 top collaborators · 30 mutual co-author links

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4 shared papersDevelopmental Biology

Revathi BalasubramanianORCID

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4 papers

Recent·Most cited

Molecular profiling implicates immune-driven adaptive homeostasis in maintaining intraocular pressure with age

Guorong Li, Nicholas G. Tolman, Abdul Hannan, Joshua B Ramkissoon, Justin Thomas Mathew, Karina Polanco, Kristin M. Perkumas, María Fernanda Suárez, Serena J Cui, Roshnni Rajkumar, Christa L. Montgomery, Krishnakumar Kizhatil, William Daniel Stamer, Simon W. M. John, Revathi Balasubramanian

The paper uses single-cell RNA sequencing to identify age-related immune remodeling in ocular outflow tissues that may help maintain intraocular pressure.

bioRxiv · Aug 20, 2026 · PreprintCell Biology

Single-Cell Characterization of Anterior Segment Development: Cell Types, Pathways, and Signals Driving Formation of the Trabecular Meshwork and Schlemm's Canal

Revathi Balasubramanian, Nicholas G. Tolman, Taibo Li, Abdul Hannan, Violet Bupp-Chickering, Karina Polanco, Aakriti Bhandari, Sally Zhou, Marina Simón, John Peregrin, Christa L. Montgomery, Krishnakumar Kizhatil, Jiang X. Qian, Simon W. M. John

The paper uses single-cell transcriptomics to characterize anterior segment development, identifying cell types, pathways, and signaling networks in trabecular meshwork and Schlemm's canal formation.

bioRxiv · Aug 15, 2025 · PreprintDevelopmental Biology

Phase transition specified by a binary code patterns the vertebrate eye cup

Revathi Balasubramanian, Xuanyu Min, Peter M. J. Quinn, Quentin Lo Giudice, Chenqi Tao, Karina Polanco, Neoklis Makrides, John Peregrin, Michael Bouaziz, Yingyu Mao, Qian Wang, Bruna Lopes da Costa, Diego F. Buenaventura, Fen Wang, Liang Ma, , Xin Zhang

The paper shows that FGF and Wnt signaling gradients determine phase transitions in vertebrate eye cup development, specifying cell fates through their combinatorial code.

Science Advances · Nov 10, 2021Peer-reviewedDevelopmental Biology

Deficient FGF signaling in the developing peripheral retina disrupts ciliary margin development and causes aniridia

Revathi Balasubramanian, Chenqi Tao, Karina Polanco, Jian Zhong, Fen Wang, Liang Ma, Xin Zhang

This study shows that FGF signaling is essential for ciliary margin development in the retina, with its disruption causing aniridia by altering the boundary between the central retina and the ciliary margin.

bioRxiv · Oct 16, 2018 · PreprintDevelopmental Biology