Sara Alehashemi

This study shows that proteasome mutations in CANDLE syndrome disrupt neuronal development by increasing polyamine levels through ODC dysregulation, and inhibiting ODC can reverse these effects.

This study identifies a STING-STAT3-SOX18 axis driving EndMT and epigenetic reprogramming in SAVI lung fibrosis, suggesting STING as a therapeutic target.

This study identifies de novo LYN variants causing constitutive Lyn kinase activation, leading to neutrophilic vasculitis and liver fibrosis, and shows therapeutic response to Src kinase inhibitors.