Author

Guibin Chen

National Institutes of HealthORCID 0000-0003-3169-3252Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Manfred BoehmiD· 2 shared Raphaela T. Goldbach‐ManskyiD· 2 shared Sara AlehashemiiD· 2 shared Adam Reinhardt· 1 shared Adam X. MirandaiD· 1 shared Adriana A. de JesusiD· 1 shared Arturo BorzutzkyiD· 1 shared Atul K. Mehta· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Manfred BoehmORCID

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2 papers

Recent·Most cited

NeuroscienceJournal of Clinical InvestigationPeer-reviewedAug 4, 2026

Proteasome mutations associated with CANDLE syndrome cause altered neuronal development by dysregulating polyamine synthesis

Clayton W. Winkler, Benjamin H. Schwarz, Katie Williams…·Karin E. Peterson

This study shows that proteasome mutations in CANDLE syndrome disrupt neuronal development by increasing polyamine levels through ODC dysregulation, and inhibiting ODC can reverse these effects.

DOI 10.1172/jci199140

humanspatial transcriptomics

𝕏 PostBluesky

Cell BiologybioRxivPreprintMar 24, 2026

STING-STAT3-SOX18 Axis Drives EndMT and Epigenetic Reprogramming in SAVI Lung Fibrosis

Dan Yang, Guibin Chen, Sachin Gaurav…·Raphaela T. Goldbach‐Mansky

This study identifies a STING-STAT3-SOX18 axis driving EndMT and epigenetic reprogramming in SAVI lung fibrosis, suggesting STING as a therapeutic target.

DOI 10.64898/2026.03.23.713256

humanbulk RNA-seq

𝕏 PostBluesky