Author

Clayton W. Winkler

National Institutes of HealthORCID 0000-0002-4460-3378Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alyssa B. EvansiD· 1 shared Audrey E. ThurmiD· 1 shared Benjamin H. SchwarziD· 1 shared Bibiana BielekovaiD· 1 shared Cathryn L. HaighiD· 1 shared Christina R. Norsten· 1 shared Cole D. KimzeyiD· 1 shared Craig MartensiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

Alyssa B. EvansORCID

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2 papers

Recent·Most cited

NeuroscienceJournal of Clinical InvestigationPeer-reviewedAug 4, 2026

Proteasome mutations associated with CANDLE syndrome cause altered neuronal development by dysregulating polyamine synthesis

Clayton W. Winkler, Benjamin H. Schwarz, Katie Williams…·Karin E. Peterson

This study shows that proteasome mutations in CANDLE syndrome disrupt neuronal development by increasing polyamine levels through ODC dysregulation, and inhibiting ODC can reverse these effects.

DOI 10.1172/jci199140

humanspatial transcriptomics

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MicrobiologybioRxivPreprintSep 16, 2025

Orthobunyavirus neurovirulence is a complex trait involving all three genome segments

Matthew J. Abbott, Christina R. Norsten, Sarah L. Anzick…·Alyssa B. Evans

This study identifies that LACV neurovirulence is a complex trait mediated by proteins on all three genome segments, with the M and S segments being primary drivers.

1 citation

mouseexperimental assay

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