Molecular BiologybioRxivPreprint
Characterization of tRNA ligase function in pathogenic fungi and trypanosomes reveals the ligase domain as a promising drug target
Khondakar Sayef Ahammed, Pedro Miramón, Lukas Schrettenbrunner…·Ambro van Hoof
The paper identifies the Trl1 sealing domain as a promising drug target for antifungal and anti-trypanosomal therapies by analyzing its essentiality in pathogenic fungi and trypanosomes.