Characterization of tRNA ligase function in pathogenic fungi and trypanosomes reveals the ligase domain as a promising drug target
Khondakar Sayef Ahammed, Pedro Miramón, Lukas Schrettenbrunner, Melissa R. Cruz, Eun Young Huh, Huiqing Hu, Bhawana Israni, Hannah B. Wilson, Ziyin Li, Soo Chan Lee, Matthew G. Blango, Danielle A. Garsin, Michael C. Lorenz, Ambro van Hoof
The paper identifies the Trl1 sealing domain as a promising drug target for antifungal and anti-trypanosomal therapies by analyzing its essentiality in pathogenic fungi and trypanosomes.
bioRxiv · Aug 20, 2026 · PreprintMolecular Biology