Author

Lingling Cheng

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-6563-507XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alexandros PertsinidisiD· 2 shared Zhangli NiiD· 2 shared Alejandra Laguillo-DiegoiD· 1 shared Bobbie Pelham‐WebbiD· 1 shared Christina S. LeslieiD· 1 shared Effie ApostolouiD· 1 shared Jieru LiiD· 1 shared Rachel A. Glenn· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Alexandros PertsinidisORCID

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2 papers

Recent·Most cited

NIPBL-mediated 3D genome folding translates enhancer priming into gene activation and safeguards lineage fidelity during embryonic transitions

Zhangli Ni, Xiaohui Ma, Stephanie Do, Lingling Cheng, Rachel A. Glenn, Thomas Vierbuchen, Alexandros Pertsinidis

This study shows NIPBL-mediated 3D genome folding is essential for enhancer-promoter communication and maintaining lineage fidelity during embryonic development.

bioRxiv · Dec 31, 2025 · PreprintGenetics

Post-mitotic transcriptional activation and 3D regulatory interactions show locus- and differentiation-specific sensitivity to cohesin depletion

UkJin Lee, Alejandra Laguillo-Diego, Wilfred Wong, Zhangli Ni, Lingling Cheng, Jieru Li, Bobbie Pelham‐Webb, Alexandros Pertsinidis, Christina S. Leslie, Effie Apostolou

This study shows that cohesin depletion affects locus- and differentiation-specific transcriptional activation and regulatory interactions in mouse ESCs, with some loops and genes being more sensitive than others.

bioRxiv · Feb 13, 2025 · PreprintMolecular Biology