Sabrina Ladstätter

The paper evaluates four organoid protocols to recreate human brain cell diversity, identifies factors affecting variability, and introduces a scoring system to assess differentiation propensities.

This study identifies Nr5a2 as a key activator of zygotic genome activation in mouse embryos, showing it regulates 72% of ZGA genes and is essential for development beyond the 2-cell stage.

The paper identifies a stress signature in brain organoid scRNA-seq data and introduces Gruffi to remove stressed cells, improving developmental accuracy.

The paper shows cohesin-dependent loop extrusion organizes zygotic chromatin into loops and domains, with distinct effects on maternal and paternal genomes.