Dscam gene triplication causes neocortical overinhibition in Down syndrome
Hao Liu, René N. Caballero-Florán, Ty Hergenreder, Tao Yang, Jacob M. Hull, Geng Pan, Ruonan Li, Macy W. Veling, Lori L. Isom, Kenneth Y. Kwan, Z. Josh Huang, Peter G. Fuerst, Paul M. Jenkins, Bing Ye
This study shows that Dscam overexpression in Down syndrome mouse models causes excessive GABAergic inhibition of neocortical pyramidal neurons.
PLoS Biology · Apr 20, 2023Peer-reviewedNeuroscience