Jacob M. Hull

The paper investigates cognitive deficits in absence epilepsy by examining thalamic-prefrontal circuit dysfunction in a mouse model, finding impaired reversal learning and identifying potential therapeutic targets.

The paper uses interpretable machine learning to derive dynamical equations from seizure data, revealing a chaotic attractor mechanism in thalamocortical circuits that drives absence seizures.

This study investigates the functional connectivity of the Reuniens nucleus to the medial prefrontal cortex, revealing prolonged recurrent excitation and potential roles in memory formation.

This study identifies molecular foci of brain aging in mice using spatiotemporal RNA-seq, showing accelerated glial aging in white matter and differential gene expression linked to neurodegenerative diseases.

This study shows that Dscam overexpression in Down syndrome mouse models causes excessive GABAergic inhibition of neocortical pyramidal neurons.

This study shows that ankyrin-G regulates forebrain connectivity and network synchronization through its interaction with GABARAP, and identifies a variant linked to bipolar disorder.