Mechanical Activation of Piezo1 by Virus-like Nanospikes to Potentiate STING-driven Macrophage Reprogramming
Jiajia Wang, Minna Sivonen, Enkhzaya Batnasan, Sini Pitkänen, Janne Tampio, Adéla Králová, Minna-Mari Tervo, Leena Latonen, Anna–Liisa Levonen, Kristiina M. Huttunen, Tarja Malm, Rashid A. Giniatullin, Vesa‐Pekka Lehto, Wujun Xu
This study shows virus-like nanospikes activate Piezo1 to enhance STING signaling in macrophages, promoting M1 polarization through mechanical and inflammatory signals.
bioRxiv · Aug 9, 2026 · PreprintImmunology