Author

Eliot L. Coffey

Whitehead Institute for Biomedical ResearchORCID 0000-0002-6579-6527Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Adan Horta· 1 shared Alicia Viridiana Zamudio· 1 shared Ann BoijaiD· 1 shared Arup K. ChakrabortyiD· 1 shared Benjamin R. SabariiD· 1 shared Chiamaka L. NwakezeiD· 1 shared Daniele CanzioiD· 1 shared Erin E. DuffyiD· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Adan Horta

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2 papers

Recent·Most cited

Enhancer features that drive formation of transcriptional condensates

Krishna Shrinivas, Benjamin R. Sabari, Eliot L. Coffey, Isaac A. Klein, Ann Boija, Alicia Viridiana Zamudio, Jurian Schuijers, Nancy M. Hannett, Phillip A. Sharp, Richard A. Young, Arup K. Chakraborty

This study identifies enhancer features that drive transcriptional condensate formation through phase separation mechanisms involving TF binding site valency, density, and affinity.

Molecular Cell · Aug 1, 2019Peer-reviewedMolecular Biology

Antisense lncRNA transcription drives stochastic Protocadherin α promoter choice

Daniele Canzio, Chiamaka L. Nwakeze, Adan Horta, Sandy M. Rajkumar, Eliot L. Coffey, Erin E. Duffy, Rachel Duffié, Kevin D. Monahan, Sean O’Keeffe, Matthew D. Simon, Stavros Lomvardas, Tom Maniatis

The paper shows antisense lncRNA transcription is required for stochastic Protocadherin promoter choice in neurons.

Cell · Apr 1, 2019Peer-reviewedGenomics