Author

Isaac A. Klein

Harvard UniversityORCID 0000-0002-6032-239XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Richard A. YoungiD· 2 shared Alan C. MulleniD· 1 shared Alicia Viridiana Zamudio· 1 shared Amin MahpouriD· 1 shared Ann BoijaiD· 1 shared Arcadia J. KratkiewicziD· 1 shared Arup K. ChakrabortyiD· 1 shared Benjamin R. SabariiD· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Richard A. YoungORCID

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2 papers

Recent·Most cited

lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation

Kaveh Daneshvar, M. Behfar Ardehali, Isaac A. Klein, Fu‐Kai Hsieh, Arcadia J. Kratkiewicz, Amin Mahpour, Sabrina Cancelliere, Chan Zhou, Brett M. Cook, Wenyang Li, Joshua V. Pondick, Sweta Gupta, Sean P. Moran, Richard A. Young, Robert E. Kingston, Alan C. Mullen

This study shows that lncRNA DIGIT and BRD3 form phase-separated condensates to regulate endoderm differentiation by interacting with H3K18ac regions.

Nature Cell Biology · Sep 7, 2020Peer-reviewedMolecular Biology

Enhancer features that drive formation of transcriptional condensates

Krishna Shrinivas, Benjamin R. Sabari, Eliot L. Coffey, Isaac A. Klein, Ann Boija, Alicia Viridiana Zamudio, Jurian Schuijers, Nancy M. Hannett, Phillip A. Sharp, Richard A. Young, Arup K. Chakraborty

This study identifies enhancer features that drive transcriptional condensate formation through phase separation mechanisms involving TF binding site valency, density, and affinity.

Molecular Cell · Aug 1, 2019Peer-reviewedMolecular Biology