Phillip A. Sharp

This paper designs prime editors with repositioned DNA breaks to significantly reduce indel errors while maintaining editing efficiency.

This study shows mutant p53R172H in pancreatic cancer enhances immunosuppressive chemokine Cxcl1 expression via enhancer activation, reducing immune checkpoint inhibitor efficacy.

The paper shows RNA exosome activity maintains transcriptional condensate stability and fluidity, which is essential for coordinated gene expression and cellular homeostasis.

The paper introduces an interpretable neural model for RNA splicing that improves RBP binding and activity predictions using an Adjusted Motif architecture.

This study introduces scGRO-seq, a single-cell nascent RNA sequencing method using click-chemistry, revealing coordinated transcription and enhancer-gene synchrony.

The paper shows maternally-expressed miRNAs repress paternally-driven genes in neurons, suggesting imprinted miRNAs mediate parental genomic conflict.

This study identifies enhancer features that drive transcriptional condensate formation through phase separation mechanisms involving TF binding site valency, density, and affinity.

The paper introduces PASTAS, a method for in vivo CRISPR screening in mice, and demonstrates its use in identifying cancer driver variants in liver tumors.

This study uses an AAV-mediated CRISPR screen in mice to identify functional suppressors of glioblastoma, revealing novel and canonical tumor suppressors and their interactions.