Jurian Schuijers

This study shows that β-catenin condensation drives the clustering of the cadherin/catenin complex and the formation of new cell-cell junctions.

The paper identifies YM155 as a β-catenin condensate inhibitor using a NECO screening platform, showing its anti-proliferative effect on WNT-driven colorectal cancer organoids.

This study identifies enhancer features that drive transcriptional condensate formation through phase separation mechanisms involving TF binding site valency, density, and affinity.