Stavros Lomvardas

This paper reports the generation of stable transgenic dwarf cuttlefish expressing fluorescent proteins using CRISPR and transposons, enabling live imaging of cell dynamics during embryonic development.

This study shows that HP1β regulates olfactory receptor choice and neuronal identity in mice by modulating H3K9me3 levels and chromatin structure, leading to changes in OR expression patterns and reduced receptor diversity.

The paper identifies a neuron type-specific microexon in Ank3/ankyrin-G that modulates calcium activity and neuronal excitability through alternative splicing.

This study shows that Mex3a regulates neuronal differentiation by controlling translation and trafficking of cell surface proteins, cilia structure, and planar cell polarity in olfactory sensory neurons.

The paper shows that opposing epigenetic forces in olfactory progenitors spatially restrict stochastic OR choice through transcription and silencing influenced by NFIA, B, and X gradients.

This study identifies nuclear architecture disruption as a mechanism underlying SARS-CoV-2 induced anosmia by analyzing human and hamster olfactory tissues.

The paper shows that zonal olfactory receptor expression in mice is regulated by chromatin structure, genome architecture, and NFIA/B/X gradients, with dorsal ORs being silenced in ventral zones.

This study shows that Setd1a-deficient mice exhibit schizophrenia-like phenotypes, which can be reversed by restoring Setd1a expression or inhibiting LSD1.

This study uses live-cell imaging to show that Sox2 transcription occurs without requiring enhancer proximity in embryonic stem cells.

The paper shows antisense lncRNA transcription is required for stochastic Protocadherin promoter choice in neurons.

The paper identifies early- and late-switch exons in neural development and shows they are regulated by RNA-binding proteins, with some neuronal subtypes lacking these regulators and retaining an immature splicing program.

The paper shows that Ldb1 facilitates trans interactions between enhancers in olfactory receptor gene expression, supporting trans enhancement as a mechanism for mammalian gene activation.

The paper identifies interchromosomal interactions in mouse olfactory sensory neurons that support stochastic gene expression during differentiation.

The paper shows that cooperative transcription factors Lhx2 and Ebf specify olfactory receptor enhancers, enabling singular OR expression through interchromosomal interactions.

The paper outlines the goals and structure of the 4D Nucleome Project, which aims to map the spatial and temporal dynamics of the genome in human and mouse cells.