Young Li

This study introduces Stereo-XCR-seq, a method for in situ single-cell T and B cell repertoire sequencing, revealing spatial heterogeneity in lymphoid aggregates in immune disorders.

The paper identifies two transcription factor clusters regulating NK cell differentiation and highlights FOSL2 and EGR2 as essential for NK cell maturation and function.

APEC improves single-cell chromatin accessibility analysis by clustering cells based on accessible regions and integrates with other tools to enhance clustering accuracy and predict gene expression and regulatory elements.