Author

William I. Padron

The University of Texas MD Anderson Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Systems Biology· 1

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Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:gene regulatory network inference· 3 Assay:scRNA-seq· 3 Assay:spatial transcriptomics· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

Kunal RaiiD· 4 shared Veena KochatiD· 4 shared Alexander J. LazariD· 3 shared Davis R. IngramiD· 3 shared Emily Zhi-Yun KeungiD· 3 shared Keila E. TorresiD· 3 shared Khalida WaniiD· 3 shared Neeta SomaiahiD· 3 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Kunal RaiORCID

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Author profile →

4 papers

Recent·Most cited

Spatially-Resolved Multiomic Atlas of Leiomyosarcoma Identifies Two Clinically Relevant Epigenetically-Driven Cell States

Ryan A. Denu, Zhao Zheng, Yingda Jiang, Suresh Satpati, Veena Kochat, Kumaren Anand, Danh D. Truong, Andrew R. Lynch, William I. Padron, Davis R Ingram, Khalida Wani, Diana Shamsutdinova, Angela D. Bhalla, Sharon M. Landers, Ravin Ratan, , Kunal Rai

This study identifies two epigenetically distinct cell states in leiomyosarcoma using single-nucleus multiome sequencing and spatial transcriptomics, linking them to clinical outcomes and therapeutic vulnerabilities.

bioRxiv · May 26, 2026 · PreprintCancer Biology

Spatially-resolved single cell atlas of liposarcoma reveals lineage hierarchies, immune niches, and regulatory circuits

Ryan A. Denu, Veena Kochat, Zhao Zheng, Suresh Satpati, Danh D. Truong, Emre Arslan, Corey Weistuch, Margarita Divenko, Manrong Wu, William I. Padron, Davis R Ingram, Khalida Wani, Wei-Lien Wang, Sharon M. Landers, Hannah C. Beird, , Kunal Rai

This study uses single-nucleus multiome sequencing and spatial transcriptomics to analyze liposarcoma subtypes, revealing distinct cellular states, immune features, and gene regulatory circuits.

bioRxiv · Mar 25, 2026 · PreprintCancer Biology

ATRX Loss Predicts Poor Outcomes and Reveals a Therapeutic Vulnerability to TEAD Inhibition in Soft Tissue Sarcomas

Ryan A. Denu, Anand Kamal Singh, Yingda Jiang, Zhao Zheng, Davis R. Ingram, Khalida Wani, Rossana Lazcano, Madison P. Ginn, Kumaren Anand, Bishal K. Singh, Jackson C. Ballard, Veena Kochat, Biji Chatterjee, William I. Padron, Sharon M. Landers, , Kunal Rai

This study shows ATRX loss in sarcomas correlates with poor outcomes and identifies TEAD inhibition as a potential therapy for ATRX-deficient tumors.

bioRxiv · Nov 23, 2025 · PreprintCancer Biology

Alternative polyadenylation regulates human urothelial differentiation

N.T. Le, Surbhi Sona, Briana A. Santo, Robert Allen Schweickart, Veena Kochat, William I. Padron, Kunal Rai, Shih‐Han Lee, Joo Mi Yi, Oliver Wessely, Byron Lee, Angela H. Ting

The paper investigates how alternative polyadenylation (APA) regulates urothelial differentiation using single-cell RNA-seq and spatial imaging, showing APA's role in shaping cell state-specific polyadenylation sites and transcriptome diversity.

bioRxiv · Mar 3, 2025 · PreprintSystems Biology