Lin Chen

Integrative Mendelian Randomization for Detecting Exposure-by-group Interactions Using Group-Specific and Combined Summary Statistics

The paper introduces int2MR, a Mendelian randomization method for detecting exposure-by-group interactions using GWAS summary statistics, showing its effectiveness in identifying sex- and age-group-specific risk factors for ADHD and Alzheimer's disease.

An integrative multi-context Mendelian randomization method for identifying risk genes across human tissues

The paper introduces mintMR, a multi-context MR framework that improves causal effect estimation by using consistent eQTLs across tissues and multi-view learning for disease-relevant tissue probabilities.

A robust two-sample Mendelian Randomization method integrating GWAS with multi-tissue eQTL summary statistics

This paper introduces a robust two-sample Mendelian Randomization method that uses GWAS and multi-tissue eQTL summary statistics to detect causal genes for schizophrenia with fewer and less independent instrumental variables.

Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits

Determinants of telomere length across human tissues

The paper examines telomere length variation across 6,391 tissue samples from 952 individuals, showing tissue-specific differences, positive correlations between tissues, and associations with age and ancestry.

IGREX for quantifying the impact of genetically regulated expression on phenotypes

IGREX quantifies the impact of genetically regulated expression on phenotypes using GWAS data and gene expression reference panels, showing significant phenotypic variation explained by GREX effects.

CCmed: cross-condition mediation analysis for identifying robust trans-eQTLs and assessing their effects on human traits

The paper introduces CCmed methods to detect robust trans-eQTLs and assess their effects on human traits by analyzing brain tissue data from GTEx and validating findings with schizophrenia GWAS data.

Insights into impact of DNA copy number alteration and methylation on the proteogenomic landscape of human ovarian cancer via a multi-omics integrative analysis

The paper introduces iProFun, a multi-omics tool to identify DNA copy number and methylation effects on proteogenomic traits in ovarian cancer, finding 500 and 122 genes with cis-associations.

The contribution of parent-to-offspring transmission of telomeres to the heritability of telomere length in humans

The paper estimates the contribution of direct telomere inheritance from parents to offspring to the heritability of leukocyte telomere length in humans.

Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis

This paper introduces GMAC, a method to identify cis-mediators of trans-eQTLs across tissues using GTEx data, improving mediation analysis by adaptively adjusting for confounders.

Co-occurring eQTLs and mQTLs: detecting shared causal variants and shared biological mechanisms

The paper identifies co-localized eQTL-mQTL pairs in Bangladeshi individuals, showing shared causal variants and mechanisms between gene expression and DNA methylation.