The paper studies tRNA gene evolution in Drosophila, finding rapid duplication and loss, sexual dimorphism in expression, and implications for regulatory diversity.

bioRxiv · Nov 24, 2025 · PreprintEvolutionary Biology

Integrative Mendelian Randomization for Detecting Exposure-by-group Interactions Using Group-Specific and Combined Summary Statistics

Ke Xu, Nathaniel Maydanchik, Bowei Kang, Jianhai Chen, Qixiang Chen, Gongyao Xu, Shinya Tasaki, David A. Bennett, Lin Chen

The paper introduces int2MR, a Mendelian randomization method for detecting exposure-by-group interactions using GWAS summary statistics, showing its effectiveness in identifying sex- and age-group-specific risk factors for ADHD and Alzheimer's disease.

PLoS Genetics · Sep 11, 2025Peer-reviewedGenetic & Genomic Medicine

Genomic Insights into the Demographic History and Local Adaptation of Wild Boars Across Eurasia

Zishuai Wang, Zixin Li, Tao Huang, Jianhai Chen, Pan Xu, Ruimin Qiao, Hongwei Holly Yin, Chengyi Song, Dongjie Zhang, Di Liu, Shuhong Zhao, Martien A. M. Groenen, Ole Madsen, Yanlin Zhang, Lijing Bai, Kui Li

The paper analyzes whole-genome data from wild boars to trace their demographic history and identify genetic signatures of local adaptation in Central Asia.

Cell Genomics · Jul 24, 2025Peer-reviewedEvolutionary Biology

The Role of Primate-Specific Genes and Network Dynamics in Cancer Evolution

Chuan Dong, Su Yang, Zhen Liao, Qian Xu, Haixia Guo, Jianhai Chen, Wen Wei, Shengqian Xia, Zhenshun Cheng, Chengjun Zhang, Feng-Biao Guo

The paper identifies primate-specific genes as more essential in cancer cell lines and shows their increased co-expression in cancer networks.

bioRxiv · Jul 23, 2025 · PreprintEvolutionary Biology

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

Jianhai Chen, Ivan Jakovlić, Mikhail Sablin, Shengqian Xia, Zhixiang Xu, Yapin Guo, Renzuo Kuang, Jie Zhong, Yangying Jia, Thuy Nhien Tran Thi, Hao Yang, Hong Mā, Nikica Šprem, Jianlin Han, Di Liu, , Shuhong Zhao

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

Genetics Selection Evolution · Jul 16, 2025Peer-reviewedEvolutionary Biology

Rapid evolution of fine-scale recombination during domestication: a perspective from population genomics

Zheng-Xi Liu, Ming Li, Xue-Hai Ge, Kun Wang, Si Si, Chang-Rong Ge, Jianhai Chen, Li-Rong Hu, Min‐Sheng Peng, Ting-Ting Yin, Ali Esmailizadeh, Chang Zhang, Lujiang Qu, Xuemei Lu, Jianlin Han, , Mingshan Wang

The paper constructs a fine-scale recombination map in domestic chickens to study rapid evolutionary changes in recombination rates during domestication.

bioRxiv · Jun 5, 2024 · PreprintEvolutionary Biology

Novel mutation leading to splice donor loss in a conserved site of DMD causes cryptorchidism

Jianhai Chen, Yangying Jia, Jie Zhong, Kun Zhang, Hongzheng Dai, Guanglin He, Fuping Li, Li Zeng, Chuanzhu Fan, Huayan Xu

The paper identifies a novel DMD mutation causing cryptorchidism through whole-genome sequencing and CRISPR-Cas9 mouse modeling.

Journal of Medical Genetics · Apr 15, 2024Peer-reviewedGenetic & Genomic Medicine

The nanopore sequencing of a Chinese rhesus macaque revealed patterns of methylation, recombination, and selection for structural variations

Jianhai Chen, Jie Zhong, Xuefei He, Ivan Jakovlić, Yong Zhang, Hao Yang, Younan Chen, Guang Yang, Chuanzhu Fan, Bairong Shen

The study uses nanopore sequencing to analyze structural variations in rhesus macaques, finding more SVs on the X chromosome and evidence of positive selection.

bioRxiv · Oct 21, 2022 · PreprintGenomics