Maria Argos

Association of polygenic risk scores with low-density lipoprotein cholesterol levels and control: findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

This study evaluates polygenic risk scores (PRS) for LDL cholesterol in a diverse Hispanic/Latino population, finding that some PRS improve prediction across subgroups but statin effectiveness varies with genetic ancestry.

Explaining the unexplained admixture mapping signals via rare variants: the HCHS/SOL

The paper investigates unexplained admixture mapping signals in the Hispanic Community Health Study/Study of Latinos by examining rare variants and expanded common variant regions, finding that common variants explain most signals.

Methylation reprogramming associated with aggressive prostate cancer and ancestral disparities

The paper investigates DNA methylation differences in prostate cancer across African, European, and Asian ancestries, finding ancestry-driven methylation patterns linked to disease aggressiveness in African tumors.

Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study

This study compares old and new local ancestry inference methods in Hispanic/Latino populations using HCHS/SOL data, finding high similarity but some regional discrepancies.

Differential prediction performance between Caribbean- and Mainland-subgroups using state-of-the-art polygenic risk scores for coronary heart disease: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

This study evaluates polygenic risk scores for coronary heart disease in Hispanic/Latino subgroups, finding better performance in Mainland compared to Caribbean subgroups.

AFA: Computationally efficient Ancestral Frequency estimation in Admixed populations: the Hispanic Community Health Study/Study of Latinos

AFA estimates ancestral allele frequencies in admixed populations with high accuracy, showing strong correlation with gnomAD frequencies in the Hispanic Community Health Study/Study of Latinos.

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

This study uses TOPMed whole genome sequences to improve imputation quality and detect rare variant associations in admixed African and Hispanic/Latino populations, identifying two novel associations with hematological traits.

The contribution of parent-to-offspring transmission of telomeres to the heritability of telomere length in humans

The paper estimates the contribution of direct telomere inheritance from parents to offspring to the heritability of leukocyte telomere length in humans.

Co-occurring eQTLs and mQTLs: detecting shared causal variants and shared biological mechanisms

The paper identifies co-localized eQTL-mQTL pairs in Bangladeshi individuals, showing shared causal variants and mechanisms between gene expression and DNA methylation.