Jennet Baltayeva

Single-cell assessment of trophoblast stem cell-based organoids as human placenta-modeling platforms

The paper compares single-cell transcriptomes of trophoblast organoids derived from hTSCs and primary CTBs to in vivo trophoblasts, identifying similarities and differences in differentiation trajectories and cell states.

Transcriptomic mapping of the metzincin landscape in human trophoblasts

The paper uses single-cell RNA sequencing to map metzincin protease expression in human first trimester trophoblasts and identifies key proteases and their substrates in different differentiation states.

Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment

The paper uses scRNA-seq to identify trophoblast states and lineage trajectories in first trimester placentas, finding BCAM as a marker of a primitive progenitor state.

Low oxygen enhances trophoblast column growth by potentiating the extravillous lineage and promoting LOX activity

This study shows low oxygen promotes extravillous trophoblast differentiation in a human placental explant model by enhancing EVT lineage commitment and LOX activity.