Wendy P. Robinson

eoPred: Predicting the placental phenotype of early-onset preeclampsia using DNA methylation

eoPred predicts the placental phenotype of early-onset preeclampsia using a 45 CpG DNA methylation signature, showing high performance in cross-validation and validation cohorts.

Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancy

This study examines DNA methylation changes in placental samples from mothers treated with SSRIs during pregnancy and finds no significant differentially methylated CpGs.

Single-cell assessment of trophoblast stem cell-based organoids as human placenta-modeling platforms

The paper compares single-cell transcriptomes of trophoblast organoids derived from hTSCs and primary CTBs to in vivo trophoblasts, identifying similarities and differences in differentiation trajectories and cell states.

A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta

The paper identifies sex-associated differentially methylated CpGs in term placenta DNA using two cohorts and links them to maternal age and birthweight.

Accurate ethnicity prediction from placental DNA methylation data

The paper develops PlaNET, a DNA methylation-based ethnicity classifier for placental samples, achieving high accuracy and outperforming existing methods in population stratification correction.

Low oxygen enhances trophoblast column growth by potentiating the extravillous lineage and promoting LOX activity

This study shows low oxygen promotes extravillous trophoblast differentiation in a human placental explant model by enhancing EVT lineage commitment and LOX activity.

Differences in DNA methylation of white blood cell types at birth and in adulthood reflect postnatal immune maturation and influence accuracy of cell type prediction

The paper examines DNA methylation differences in white blood cell types between newborn and adult blood, showing how these changes reflect immune maturation and affect cell type prediction accuracy.

The value of DNA methylation profiling in characterizing preeclampsia and intrauterine growth restriction

This study identifies DNA methylation changes in early-onset preeclampsia, late-onset preeclampsia, and normotensive intrauterine growth restriction, revealing distinct methylation clusters and potential clinical subgroups.