Gregg A. Duncan

This study shows that adding lung surfactant Poractant alfa to lipid nanoparticles improves their performance for pulmonary mRNA delivery, increasing transfection efficiency and particle concentration.

This paper develops a PEG-based hydrogel for intranasal drug delivery that forms in situ without physiological triggers, improving drug residence time and bioavailability.

This study shows that MUC5B and MUC5AC regulate mucociliary transport in airway epithelium by altering mucus biophysical properties based on their relative abundance.

The paper introduces an inverse Transwell assay to study mucus barrier function against respiratory viruses and identifies MUC5AC's role in antiviral defense.

This paper shows that mesophase spacing in liquid crystalline nanocarriers predicts hydrophilic payload release kinetics, linking material composition to functional performance.

This study shows that airway mucus inhibits neutrophil extracellular traps (NETs) in a sialic acid-dependent manner, and mucus dysfunction in disease can impair this regulation.

The paper characterizes gene regulatory networks in human airway epithelial cells and identifies cell type-specific responses to type I interferon.

This study shows that myeloperoxidase impairs mucociliary transport in human airway epithelium by increasing airway surface liquid viscosity, similar to neutrophil elastase.

This study investigates how the extracellular matrix affects AAV gene therapy by comparing diffusion and transduction efficiency across different AAV serotypes and ECM models.

This study develops synthetic mucin-based hydrogels for localized delivery of anti-TNF- antibodies in IBD, showing improved retention and reduced systemic exposure.

This study evaluates how linear and branched PEGylation affects nanoparticle uptake and distribution in tumor and immune cells, showing branched PEG increases spleen accumulation and linear PEG enhances tumor uptake by immune cells.

This study evaluates AAV6-mediated MUC5AC siRNA delivery to reduce mucin overexpression and improve mucociliary clearance in asthma models.

This study shows that female sex hormones enhance gonococcal colonization at the endocervix by altering mucus production and structure, increasing bacterial microcolony size and number.

This study shows synthetic mucus biomaterials reduce Pseudomonas aeruginosa biofilm thickness and viability when combined with DNase and/or -amylase.

This paper develops rapid in situ forming PEG hydrogels for mucosal drug delivery that degrade naturally and adhere to mucus-coated tissues.

This study investigates how tissue-specific ECM properties affect nanoparticle diffusion and cellular uptake, finding that PEGylation strategy impacts ECM penetration and uptake differently across tissues.

This paper describes a method to isolate airway mucins from pig trachea at a large scale for pulmonary disease research, showing higher mucin content and microviscosity compared to gastric mucins and human mucus.