Shawn Chen

Design of Fluorescent Membrane Scaffold Proteins for Nanodiscs

The paper develops fluorescent membrane scaffold proteins for nanodiscs, enabling applications like monitoring membrane protein interactions through fluorescence resonance energy transfer.

Lineage-Specific Epigenomic Mapping of Proximal and Distal Fallopian Tube Epithelium Reveals Mesenchymal/Wnt-Driven Tumor Phenotype Diversification

The paper compares epigenomic and transcriptional differences between proximal and distal fallopian tube epithelium in mouse models, revealing distinct tumor subtypes driven by EMT and WNT pathways.

GenVS TBDB: A Target-Aware AI-Generated and Virtual Screened Small-Molecule Library for Tuberculosis Drug Discovery

This paper introduces GenVS-TBDB, an AI-generated and virtual-screened small-molecule library targeting Mycobacterium tuberculosis, identifying bioactive compounds with potential for tuberculosis drug discovery.

Intron-targeted mutagenesis reveals roles for Dscam1 RNA pairing-mediated splicing bias in neuronal wiring

The paper shows that specific Dscam1 isoform splicing biases are required for precise mushroom body axonal wiring in Drosophila, with variable domain-specific effects.