Author

Heng Wang

Dana-Farber Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:graph neural network· 1 Organism:mouse· 1

Frequent Co-Authors

Charles Stiles· 1 shared Christopher J. GraseriD· 1 shared Daphne Adele Haas-KoganiD· 1 shared Dipanjan ChowdhuryiD· 1 shared Franziska Michor AiD· 1 shared Gengwei Xu· 1 shared Genhui Xiao· 1 shared Graeme Smith· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Charles Stiles

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

H3K27M-driven hypertranscription leads to a new targetable dependency in diffuse midline gliomas

Sharmistha Pal, Heng Wang, Jacob Geisberg, Tasmia Mirza, Khushi Kohli, А. Ш. Назаретян, Truman Knowles, Christopher J. Graser, Kaitlyn Bootz, Olga Wójcikowska, Magda Bartyńska, Simon J. Boulton, Jayesh B. Majithiya, Helen Robinson, Graeme Smith, , Daphne Adele Haas-Kogan

This study identifies hypertranscription as a vulnerability in H3K27M-driven diffuse midline gliomas, showing ATR inhibition effectively targets this feature in preclinical models.

bioRxiv · May 15, 2026 · PreprintCancer Biology

GenVS TBDB: A Target-Aware AI-Generated and Virtual Screened Small-Molecule Library for Tuberculosis Drug Discovery

Xiaoying Lv, Han Jie Guo, JingLan Wang, Qiping Hu, Mengyun Zhang, Heng Wang, Genhui Xiao, Xueying Zheng, Xi Lu, Zhuo Tang, Kai Yu, Gengwei Xu, Shawn Chen, Rumin Zhang, Jinjiang Guo

This paper introduces GenVS-TBDB, an AI-generated and virtual-screened small-molecule library targeting Mycobacterium tuberculosis, identifying bioactive compounds with potential for tuberculosis drug discovery.

bioRxiv · Apr 28, 2025 · PreprintPharmacology & Toxicology