Jongsam Ahn

The β-lactam adjuvant guanosine potentiates anti-folate antibiotics and pyrimidine synthesis inhibitors by depleting thymidine in methicillin-resistant Staphylococcus aureus

This paper shows that guanosine, a β-lactam adjuvant, enhances the effectiveness of antifolate antibiotics and pyrimidine inhibitors by depleting thymidine in MRSA.

A thermodynamic bottleneck in the TCA cycle contributes to acetate overflow in Staphylococcus aureus

This study identifies a thermodynamic bottleneck in the TCA cycle of S. aureus that favors acetate overflow metabolism for bioenergetic efficiency.

An integrated computational and experimental study to elucidate Staphylococcus aureus metabolism

This study integrates computational modeling and experimental validation to refine a genome-scale metabolic model of S. aureus, improving its accuracy in predicting gene essentiality and metabolic capabilities.