Author

Aaron Christopher Nolan

Ollscoil na Gaillimhe – University of GalwayORCID 0009-0006-1946-0842Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

James P. O’GaraiD· 2 shared Merve Suzan ZedeniD· 2 shared Dhananjay Shinde· 1 shared Jessica Blaise KellyiD· 1 shared Jongsam AhniD· 1 shared Sarah ByrneiD· 1 shared Vinai Chittezham ThomasiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

James P. O’GaraORCID

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2 papers

Recent·Most cited

MicrobiologyAntimicrobial Agents and ChemotherapyPeer-reviewedJun 10, 2026

The β-lactam adjuvant guanosine potentiates anti-folate antibiotics and pyrimidine synthesis inhibitors by depleting thymidine in methicillin-resistant Staphylococcus aureus

Aaron Christopher Nolan, Jessica Blaise Kelly, Jongsam Ahn…·James P. O’Gara

This paper shows that guanosine, a β-lactam adjuvant, enhances the effectiveness of antifolate antibiotics and pyrimidine inhibitors by depleting thymidine in MRSA.

1 citation

humanmouse

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MicrobiologybioRxivPreprintMay 25, 2026

Purine and pyrimidine analogues differentially regulate cell wall precursor biosynthesis to control β-lactam susceptibility in methicillin resistant Staphylococcus aureus

Aaron Christopher Nolan, Sarah Byrne, Merve Suzan Zeden, James P. O’Gara

This paper shows that pyrimidine analogues enhance β-lactam antibiotics against MRSA by altering cell wall precursor biosynthesis, while the purine analogue 6-TG has antagonistic effects.

DOI 10.64898/2026.05.24.727567

bacteria (other)proteomics

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