James P. O’Gara

This paper shows that guanosine, a β-lactam adjuvant, enhances the effectiveness of antifolate antibiotics and pyrimidine inhibitors by depleting thymidine in MRSA.

This paper shows that pyrimidine analogues enhance β-lactam antibiotics against MRSA by altering cell wall precursor biosynthesis, while the purine analogue 6-TG has antagonistic effects.

This study identifies a S180F substitution in D-alanine aminotransferase (Dat) in Staphylococcus aureus that confers resistance to β-chloro-D-alanine by altering PLP co-factor binding and promoting antibiotic inactivation.